H Lochs Selected Research

Trimetrexate (JB11)

1/2002	Trimetrexate as biochemical modulator of 5-fluorouracil/leucovorin in advanced colorectal cancer: final results of a randomised European study.
5/2000	Sequential trimetrexate, 5-fluorouracil and folinic acid are effective and well tolerated in metastatic colorectal carcinoma. The phase II study group of the AIO.

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H Lochs Research Topics

Disease

13	Crohn Disease (Crohn's Disease) 02/2009 - 02/2000
8	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 10/2007 - 08/2000
6	Malnutrition (Nutritional Deficiencies) 10/2012 - 12/2000
6	Liver Cirrhosis (Hepatic Cirrhosis) 10/2012 - 06/2000
6	Ulcerative Colitis 11/2005 - 01/2001
4	Body Weight (Weight, Body) 11/2005 - 11/2002
4	Neoplasms (Cancer) 01/2005 - 10/2000
3	Inflammation (Inflammations) 01/2016 - 10/2009
3	Neoplasm Metastasis (Metastasis) 06/2011 - 09/2000
3	Necrosis 10/2009 - 08/2000
3	Hemorrhage 10/2006 - 12/2003
3	Fibrosis (Cirrhosis) 05/2003 - 03/2000
2	Hepatic Encephalopathy 07/2010 - 06/2000
2	Hepatocellular Carcinoma (Hepatoma) 07/2007 - 03/2000
2	Colitis 03/2006 - 06/2004
2	Acromegaly 02/2006 - 01/2000
2	Pain (Aches) 09/2005 - 08/2002
2	Carcinoma (Carcinomatosis) 05/2004 - 02/2004
2	Cushing Syndrome 02/2004 - 12/2000
2	Lactose Intolerance (Intolerance, Lactose) 05/2003 - 01/2003
2	Ascites 05/2003 - 12/2000
2	Metaplasia 01/2003 - 08/2002
2	Colorectal Neoplasms (Colorectal Cancer) 01/2002 - 05/2000
2	Diabetes Mellitus 05/2001 - 04/2000
2	Hyperlipidemias (Hyperlipidemia) 05/2001 - 04/2000
2	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 02/2001 - 01/2001
1	Melanoma (Melanoma, Malignant) 06/2011
1	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 10/2009
1	Common Variable Immunodeficiency 03/2008
1	Anaphylaxis (Anaphylactic Shock) 03/2008
1	Insulinoma 07/2007
1	Irritable Bowel Syndrome (Syndrome, Irritable Bowel) 03/2007
1	Angiodysplasia 10/2006
1	Liver Diseases (Liver Disease) 08/2006
1	Renal Insufficiency (Renal Failure) 08/2006
1	Communicable Diseases (Infectious Diseases) 08/2006
1	Frailty 04/2006
1	Hepatitis 02/2006
1	Drug-Related Side Effects and Adverse Reactions 02/2006
1	Acute Hemorrhagic Pancreatitis 01/2006
1	Pancreatitis 01/2006

Drug/Important Bio-Agent (IBA)

6	Capsules (Microcapsules)IBA 06/2011 - 12/2003
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2016 - 02/2002
3	Proteins (Proteins, Gene)FDA Link 07/2010 - 12/2000
3	EnzymesIBA 10/2009 - 01/2003
3	Glutamine (L-Glutamine)FDA Link 10/2007 - 06/2000
3	Thalidomide (Thalomid)FDA Link 10/2006 - 02/2002
3	Lamin Type A (Lamin A)IBA 02/2001 - 04/2000
2	Interleukin-10 (Interleukin 10)IBA 10/2009 - 08/2000
2	Insulin (Novolin)FDA Link 07/2007 - 04/2000
2	Glucose (Dextrose)FDA LinkGeneric 07/2007 - 01/2000
2	Anti-Bacterial Agents (Antibiotics)IBA 03/2007 - 04/2006
2	NitrogenIBA 11/2005 - 11/2002
2	Amino Acids FDA Link 11/2005 - 06/2000
2	HydrogenIBA 05/2003 - 01/2003
2	Genetic Markers (Genetic Marker)IBA 05/2003 - 01/2003
2	DNA (Deoxyribonucleic Acid)IBA 05/2003 - 01/2003
2	GlucocorticoidsIBA 02/2003 - 08/2000
2	SteroidsIBA 02/2003 - 05/2001
2	CytokinesIBA 02/2002 - 08/2000
2	Leucovorin (Folinic Acid)FDA Link 01/2002 - 05/2000
2	Fluorouracil (Carac)FDA LinkGeneric 01/2002 - 05/2000
2	Trimetrexate (JB11)FDA Link 01/2002 - 05/2000
2	Peptides (Polypeptides)IBA 12/2000 - 10/2000
1	Interleukin-6 (Interleukin 6)IBA 01/2016
1	C-Reactive ProteinIBA 01/2016
1	Fibrinogen (Factor I)FDA Link 01/2016
1	SugarsIBA 10/2012
1	Branched-Chain Amino AcidsIBA 07/2010
1	GlycogenIBA 07/2010
1	InterleukinsIBA 10/2009
1	ImmunosorbentsIBA 10/2009
1	Immunoglobulin G (IgG)IBA 03/2008
1	Immunoglobulin A (IgA)IBA 03/2008
1	Immunoglobulins (Immunoglobulin)IBA 03/2008
1	Blood Glucose (Blood Sugar)IBA 07/2007
1	Hemoglobins (Hemoglobin)IBA 10/2006
1	Rifaximin (L 105)FDA Link 04/2006
1	Insulin-Like Growth Factor I (IGF-1)IBA 02/2006
1	pegvisomant FDA LinkGeneric 02/2006
1	Transaminases (Aminotransferases)IBA 02/2006
1	fish oil triglyceridesIBA 01/2006
1	ClinOleicIBA 01/2006
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2006
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2006
1	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 01/2006
1	Thiobarbituric Acid Reactive SubstancesIBA 01/2006

Therapy/Procedure

13	Therapeutics 07/2010 - 01/2000
3	Critical Care (Surgical Intensive Care) 02/2009 - 08/2006
3	Transjugular Intrahepatic Portasystemic Shunt 10/2004 - 06/2000
2	Surgical Portasystemic Shunt (Portosystemic Shunt) 10/2004 - 06/2000
2	Drug Therapy (Chemotherapy) 05/2000 - 03/2000
1	Cardiopulmonary Bypass (Heart-Lung Bypass) 10/2009
1	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 10/2009
1	Radiofrequency Ablation 07/2007
1	Organ Transplantation 08/2006
1	Oral Administration 04/2006
1	Operative Surgical Procedures 04/2006
1	Secondary Prevention 04/2006
1	Parenteral Nutrition 01/2006